B.S., University of Maine
M.S., Virginia Tech and State University
Ph.D., Virginia Tech and State University
Description of Research Interests
A. Hormonal role in mammary cell differentiation and induction of lactation in dairy cattle.
B. Drug efficacy studies for treatment of mastitis in both lactating and nonlactating cows.
C. Histopathologic and ultrastructural aspects of induced Staphylococcus aureus mastitis in the bovine.
D. Microbiological aspects of bovine mastitis and evaluation of commercial identification systems.
E. Role of extracellular bacterial toxins in mammary inflammation.
F. Cytoskeletal role in exocytosis of milk constituents from mammary epithelial cells in vitro .
G. Role of microtubules in prolactin-dependent mammary cell differentiation and during involution.
H. Evaluation of metabolic inhibitors in protein and carbohydrate synthesis and secretion, and amino acid uptake in mammary epithelium.
I. Development and propagation of monoclonal antibodies to cell-surface components of bovine leukocytes and identification of neutrophil subsets.
J. Evaluation of the Fossomatic cell counter for enumerating somatic cells in milk.
K. Effect of colchicine on mammary differentiation and milk production in dairy heifers.
L. Effects of antibiotics on bovine blood and milk neutrophil viability, phagocytosis, and ultrastructure.
M. Effects of antibiotic infusion products on milk synthesis and secretion.
N. Mechanics of leukocyte migration into mammary secretions and effects on alveolar integrity.
O. Local production of immunoglobulins in the mammary gland with special references to plasma cells in teat end tissues.
P. Enhancement of mammary immunity via immunostimulation of teat end tissues.
Q. Amyloidosis in the bovine mammary gland.
R. Evaluation of postmilking teat sanitizers in mastitis control.
S. Histologic and biochemical changes accompanying mammary involution.
T. Role of myoepithelial cells and ultrastructural aspects of milk ejection.
U. Effects of machine milking, vacuum level, and fluctuation on teat end morphology and ultrastructure.
V. Role of Corynebacterium bovis in the biological control of mastitis.
W. Prevalence and pathology of beef cow mastitis.
X. New treatment strategies for intramammary/intramuscular therapy.
Y. Prevalence of intramammary infection in breeding age dairy heifers.
Z. Effects of bovine somatotropin (BST) on incidence of bovine mastitis.
Selected Recent Publications
Gillespie, B. E., W. E. Owens, S. C. Nickerson, and S. P. Oliver. Deoxyribonucleic acid fingerprinting of Staphylococcus aureus from heifer mammary secretions and from horn flies. Journal of Dairy Science. 82 :1581-1585. 1999.
Nickerson, S. C., W. E. Owens, L. K. Fox, C. C. Schleifenger, T. R. Shryock, and T. E. Spike. Comparison of tilmicosin and cephapirin as therapeutics for Staphylococcus aureus mastitis at dry-off. Journal of Dairy Science. 82 :696-703. 1999.
Nickerson, S. C., W. E. Owens, G. M. Tomita, and P. W. Widel. Vaccinating dairy heifers with a Staphylococcus aureus bacterin reduces mastitis at calving. Large Animal Practice. 20 :16-28. 1999.
Owens, W. E., S. C. Nickerson, and C. H. Ray. Efficacy of parenterally or intramammarily administered tilmicosin or ceftiofur against Staphylococcus aureus mastitis during lactation. Journal of Dairy Science. 82 :645-647. 1999.
Bramley, A. J., R. N. Gonzalez, R. J. Harmon, J. S. Hogan, S. C. Nickerson, S. P. Oliver, J. W. Pankey, and K. L. Smith. Laboratory and Field Handbook on Bovine Mastitis. Second Edition. National Mastitis Council, Inc. Madison , WI . 1999.
Committee on Drug Use in Food Animals. The Use of Drugs in Food Animals. Benefits and Risks. National Research Council, Institute of Medicine , National Academy Press, Washington , D.C. 1999.
Boddie, R. L., S. C. Nickerson, and R. W. Adkinson. Efficacies of chlorine dioxide and iodophor teat dips during experimental challenge with Staphylococcus aureus and Streptococcus agalactiae. Journal of Dairy Science. 83 : 2975-2979. 2000.
Nickerson, S. C., W. Owens, and S. M. DeRouen. E. Mastitis prevalence in first calf beef heifers and effects on calf weaning weight. Large Animal Practice. 21 :20-23. 2000.
Owens, W. E., S. C. Nickerson, R. L. Boddie, and C. H. Ray . The effect of methoprene on horn fly numbers and mastitis in dairy heifers. Large Animal Practice. 21 :26-28. 2000.
Simpson, R. B., S. C. Nickerson, J. D. Shockey, and J. M. Phillip. Prevalence of mastitis pathogens preceding and following parturition in primiparous beef cows. The Professional Animal Scientist. 16 :188-195. 2000.
Tomita, G. M., C. H. Ray, S. C. Nickerson, W. E. Owens, and G. F. Gallo. A comparison of two commercially available Escherichia coli vaccines against E. coli intramammary challenge. Journal of Dairy Science 83 : 2276-2281. 2000.
Philpot, W. N., and S. C. Nickerson. Winning the Battle Against Mastitis. Westfalia-Surge, Naperville , IL . 188 pages. 2000.
Owens, W. E., S.C. Nickerson, R. L. Boddie, G. M. Tomita and C. H. Ray . Prevalence of mastitis in dairy heifers and effectiveness of antibiotic therapy. Journal of Dairy Science. 84 :814-817. 2001.
Owens, W. E., S. C. Nickerson, and C. H. Ray . Effect of pour-on and fly tag insecticide combination in controlling horn flies and Staphylococcus aureus mastitis in diary heifers. Veterinary Therapeutics (In press). 2001.
Boddie, R. L., and S. C. Nickerson . Reduction of mastitis caused by experimental challenge with Staphylococcus aureus and Streptococcus agalactiae by use of a quaternary ammonium and halogen-mixture teat dip. Journal of Dairy Science. 85 :258-262. 2002.
Boddie, R. L., W. E. Owens, C. H. Ray, and S. C. Nickerson. Germicidal activities of representatives of five different teat dip classes against three bovine mycoplasma species using a modified excised teat model. Journal of Dairy Science. 85 :1909-1912. 2002.
Nickerson, S. C. Mastitis therapy and control: Management control options. Pages 11740-1746 in Encyclopedia of Dairy Sciences. Volume 3. Roginski, H., J. W. Fuquay, and P. F. Fox (eds). Academic Press, London . 2002.
Nickerson, S. C . Mammary resistance mechanisms: Anatomical. Pages 1697-1701 in Encyclopedia of Dairy Sciences. Volume 3. Roginski, H., J.W. Fuquay, and P. F. Fox (eds). Academic Press, London . 2002.
Nickerson, S. C . Mammary gland anatomy: Anatomy. Pages 1680-1688 in Encyclopedia of Dairy Sciences. Volume 3. Roginski, H., J.W. Fuquay, and P. F. Fox (eds). Academic Press, London . 2002.
Owens, W. E., S. C. Nickerson, and C. H. Ray. Effect of pour-on and fly tag insecticide combi nation in controlling horn flies and Staphylococcus aureus mastitis in dairy heifers. American Journal of Veterinary Science. In Press. 2003.