Research in my lab is focused on understanding the role of nutritional factors that regulate metabolic activity. Some of the methods we employ are mouse models of diet-induced obesity, exercise (both chronic and acute), or gene knockout/overexpression to study nutrient mediated control of fatty acid oxidation, glucose uptake, and insulin signaling. Our lab also uses molecular and cellular biology methods to study nutrient mediated effects on transcriptional regulation of metabolism.
Identification of bioactive food components that modify DNA transcriptional activity.
Epigenetic alterations of metabolic pathways though active DNA demethylation.
Selected Recent Publications
Paton CM, Vaughan RA, Alpergin ES, Assadi-Porter F, Dowd MK. Dihydrosterculic acid from cottonseed oil suppresses desaturase activity and improves liver metabolomic profiles of high fat fed mice. Nutr Res. 2017 Sep;45:52-62. Epub 2017 Jul 4.
Stevenson JL, Paton CM, Cooper JA. Hunger and satiety responses to high-fat meals after a high polyunsaturated fat diet. Nutrition. 2017 Sep;41:14-23. Epub 2017 Mar 29.
Krishnan S, Steffen L, Paton CM, Cooper JA. Impact of dietary fat composition on prediabetes – a 12-year follow up study. Public Health Nutr. 2017 Jan 31:1-10.
Stevenson JL, Miller MK, Skillman HE, Paton CM, Cooper JA. A PUFA-rich diet improves fat oxidation following saturated fat-rich meal. Eur J Nutr. Epub 2016 May 12.
Stamatikos AD, da Silva RP, Lewis JT, Douglas DN, Kneteman NM, Jacobs RL, and Paton CM. Tissue specific effects of dietary carbohydrates and obesity on ChREBPα and ChREBPβ expression. Lipids. 2016 Jan;51(1):95-104.
Kang M, Vaughan RA, Paton CM. Fibrin degradation fragment-E induces adipocyte inflammation and suppresses insulin-stimulated glucose disposal in vitro. Am J Physiol Cell Physiol. 2015 Dec 1;309(11):C767-74.
Vaughan RA, Garrison RL, Stamatikos AD, Kang M, Cooper JA, and Paton CM. A high linoleic acid diet does not induce inflammation in mouse liver or adipose tissue. Lipids 2015 Nov;50(11):1115-22.
Chang H, Kozimor AL, Paton CM, and Cooper JA. Acute effect of dietary fatty acid composition on postprandial metabolism in women. Exp Physiol. 2014 Sep;99(9):1182-90.
Stamatikos AD & Paton CM. Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism. Am J Physiol Endocrinol Metab. 2013 Oct;305(7):E767-E775.
Rogowski MP, Flowers MT, Stamatikos AD, Ntambi JM, Paton CM. SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in mice. J Lipid Res. 2013 Oct;54(10):2636-46.
Cooper JA, Manini T, Paton CM, Yamada Y, Everhart JE, Cummings S, Mackey DC, Newman AB, Glynn NW, Tylavsky F, Harris T, and Schoeller DA. Longitudinal change in energy expenditure and effects on energy requirements of the elderly. Nutr J. 2013 Jun 6;12(1):73.
Paton CM, Rogowski MP, Kozimor AL, Stevenson JL, Chang H, Cooper JA. Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women. Obesity. 2013 Dec;21(12):E640-8.
Flowers MT*, Paton CM*, O’Byrne SM, Schiesser KJ, Dawson, J, Blanner WS, Kendziorski C, Ntambi JM. Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. PLoS One 2011 May 9;6(5):e19734 . (*Authors contributed equally).
Cooper JA, Watras AC, Paton CM, Wegner FH, Adams AK, Schoeller DA. Impact of Exercise and Dietary Fatty Acid Composition from a High-fat Diet on Markers of Hunger and Satiety. Appetite 2011 Feb;56(1):171-8.
Paton CM and Ntambi JM. Loss of stearoyl-CoA desaturase activity promotes ER stress induced Xbp-1 splicing and increases free cholesterol synthesis. Am J Physiol Endocrinol Metab (October 5, 2010).
Liu X, Miyazaki M, Flowers MT, Sampath H, Zhao M, Chu K, Paton CM, and Ntambi JM. Loss of Stearoyl-CoA desaturase-1 attenuates adipose inflammation: distinct roles of adipocyte-derived lipoprotein lipase and oleate. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):31-8. Epub 2009 Nov 12
Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M, Ntambi JM. Skin-specific deletion of Stearoyl-CoA Desaturase-1 alters skin lipid composition and protects mice from high-fat diet induced obesity. Journal of Biological Chemistry. 2009 Jul 24;284(30):19961-73.
Paton CM & Ntambi JM. Biochemical and Physiological Function of Stearoyl-CoA Desaturase. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E28-37. Epub 2008 Dec 9.