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Mycotoxin Detection in Dried Blood

Development and Validation of Methods for Detection of Mycotoxins Exposure in Dried Spotted Blood Samples (DBS)


  • University of Georgia Graduate student Amanda Seawright works in the lab.
    University of Georgia Graduate student Amanda Seawright works in the lab.
  • This diagram shows the procedure for analyzing dried blood samples.
    This diagram shows the procedure for analyzing dried blood samples.
  • Q&A with Jia-Sheng Wang
    Q&A with Jia-Sheng Wang
  • Dried blood samples were prepared from rats treated with single or repeat-dose of AFB1 and from people whose blood was spiked with known levels of AFB-Lys adduct, as well as serum samples from Kenya and Uganda for validation studies. Photo courtesy of Emily Urban.
    Dried blood samples were prepared from rats treated with single or repeat-dose of AFB1 and from people whose blood was spiked with known levels of AFB-Lys adduct, as well as serum samples from Kenya and Uganda for validation studies. Photo courtesy of Emily Urban.

The goal of this project is to establish and validate methods for measuring major mycotoxin biomarkers, especially for aflatoxin-lysine adduct, in human dried blood spot (DBS) samples for supporting urgent needs of nutrition impact and intervention studies conducted in Asia and Africa countries by PMIL, as well as the Nutrition Innovation Laboratory at Tufts University.

The methods are being validated and applied to assess susceptibility factors in determination of human aflatoxicosis, to evaluate the linkage between aflatoxin exposure and human nutrition deficiency and growth retardation and developmental inhibition in children.


Lead Scientist

Dr. Jia-Sheng Wang, Professor and Department Head

More about Wang

Research Collaborators

Cornell University

  • Dr. Dan Brown

Eduardo Mondlane University

  • Ms. Lourena Arone

International Crops Research Institute for the Semi-Arid Tropics

  • Dr. Samuel Njoroge

National Small Holder Farmers Association of Malawi

  • Mr. Aubrey Chinseu

Tufts University

  • Dr. Jeffrey Griffiths
  • Dr. Patrick Webb

University of Georgia

  • Dr. Timothy Brenneman
  • Dr. Bob Kemerait
  • Dr. Lili Tang

University of Ghana

  • Dr. Nii-Ayi Ankrah
  • Mr. Justus Kumi

Zambia Agriculture Research Institute

  • Dr. Mweshi Mukanga

Institution

University of Georgia Logo

Research Locations

Ghana, Haiti, Malawi, Mozambique, and Zambia

Duration

September 26, 2013 - July 31,2017

Award No.

AID-ECG-A-00-07-0001

Sub-Award Amount:

$630,772