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Mosquito hormones similar to humans By April Reese Sorrow

Mosquitoes fly, drink blood, and can live for days without a head. Mosquitoes may seem very different from humans, but one University of Georgia researcher says people have a lot in common with the notorious insect.

“We know that insulin is an important hormone for controlling sugar metabolism in humans. It surprises people that insects also have an insulin,” said Mark Brown, an internationally known mosquito biologist with the UGA College of Agricultural and Environmental Sciences.

Understanding those similarities, and the differences, could lead to better mosquito controls and a reduction in the diseases they can carry.

Reproduction

Insulin-like peptides control parts of metabolism in a sugar-fed mosquito. But in a blood-fed mosquito, those same peptides “turn on her ovaries to make steroid hormones, just like in humans,” he said. “Ultimately, three to four days later, the female is ready to lay her eggs.”

Female mosquitoes need blood to digest and provide nutrients for egg maturation. Brown identifies and studies the hormones released by mosquitoes and the functions affected by those hormones.

Female mosquitoes live less than a month and take a blood meal every three to four days.

Evolution

Insects have genes for 40 different peptide hormones. The function of many of those is still a mystery. Brown is working to solve the mystery by studying the evolution of these peptide hormones and how their function and structure are preserved.

“Basically the same kinds of hormones that work in us are at work in insects,” he said. “The evolution and conservation of these hormones are amazing.”

Disease transmission

Mosquitoes infect millions of people around the world with parasitic diseases like malaria. Malaria is one of the leading causes of sickness and death in the developing world. According to World Health Organization statistics, malaria caused 1 million deaths in 2008, mostly among African children.

When female mosquitoes take blood meals, they can pick up viruses that cause other human diseases in humans, like dengue or yellow fever. They also transmit nematodes that become heartworms in animals. The disease pathogens multiply in the mosquito. When the mosquito takes another meal, the pathogens can pass to another host through the mosquito's saliva.

Brown said understanding the regulation of reproduction in mosquitoes can give researchers insight on how pathogens can multiply in the female’s body during a reproductive cycle.

Knowing how mosquitoes translate chemical messages inside their bodies could help scientists develop ways to control mosquito populations, he said. For example, they might be able to disguise a chemical, or a mimic, to disrupt chemical messages and prevent the mosquito from reproducing.

The National Institutes of Health and the United States Department of Agriculture fund Brown’s research.

(April R. Sorrow is a science writer with the University of Georgia Public Affairs Office.)

Mosquito close
Mosquito close

Mosquitoes feed on sugar water in Mark Brown's endocrinology lab on UGA's Athens campus.

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Mosquitoes feed on sugar water in Mark Brown's endocrinology lab on UGA's Athens campus. Download Image
Mosquito cage
Mosquito cage

Mosquito cage in Mark Brown's mosquito endocrinology lab on the UGA Athens campus.

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